Blue Rubber Bleb Nevus Syndrome
Blue rubber bleb nevus syndrome (BRBNS) is a rare vascular anomaly syndrome consisting of multifocal venous malformations (VM). The malformations are most prominent in the skin, soft tissues, and gastrointestinal (GI) tract, but may occur in any tissue. This association of “hemangiomas” of the skin and GI tract was first reported in 1860,1 and fully characterized by William Bean in 1958, giving rise to the eponym “Bean syndrome.